Mechanochromic Luminescence (MCL) of Purely Organic Two?Component Dyes: Wide?Range MCL over 300 nm and Two?Step MCL by Charge?Transfer Complexation

Discovery of Hippo in MCL.

ment therapy for inherited enzyme deficiency–macrophagetargeted glucocerebrosidase for Gaucher’s disease. N Engl J Med. 1991;324(21):1464-1470. 4. Elstein D, Dweck A,1 Attias D, et al. Oral maintenance clinical trial with miglustat for type I Gaucher disease: switch from or combination with intravenous enzyme replacement. Blood. 2007;110(7):2296-2301. 5. Robertson PL, Maas M, Goldblatt J. Semiq...

Ighv Genes in Mcl

Alba Navarro, Guillem Clot, Cristina Royo, Pedro Jares, Anastasia Hadzidimitriou, Andreas Agathangelidis, Vasilis Bikos, Nikos Darzentas, Theodora Papadaki, Itziar Salaverria, Magda Pinyol, Xavier Puig, Jara Palomero, Maria Carmela Vegliante, Virgina Amador, Alejandra Martinez-Trillos, Lenka Stefancikova, Adrian Wiestner, Wyndham Wilson, Christiane Pott, Maria Jose Calasanz, Nicola Trim, Wendy ...

Surgeon-Major A.E. McL. Ross

Mcl-1 Ubiquitination and Destruction

Loss of the Fbw7 tumor suppressor is common in diverse human cancer types, including T-Cell Acute Lymphoblastic Leukemia (T-ALL), although the mechanistic basis of its anti-oncogenic activity remains largely unclear. We recently reported that SCFFbw7 regulates cellular apoptosis by controlling the ubiquitination and destruction of the pro-survival protein, Mcl-1, in a GSK3 phosphorylation-depen...

Regulation of neutrophil apoptosis by Mcl-1.

Neutrophils rapidly undergo spontaneous apoptosis, but this process can be considerably delayed by exposure to a variety of agents such as pro-inflammatory cytokines. The anti-apoptotic protein of the Bcl-2 family, Mcl-1, plays a key role in the regulation of neutrophil apoptosis. The protein has some unusual properties compared with other family members, including an extremely high turnover ra...